Images of Cells Exposed to COVID-19 Vaccine Reveal Native-Like Coronavirus Spikes
April 7, 2021
https://globalbiodefense.com/2021/04/07/....The study:
Native-like SARS-CoV‑2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine
https://pubs.acs.org/action/cookieAbsentKey excerpts:
ChAdOx1 nCoV-19/AZD1222 [vaccine] (hereafter referred to as ChAdOx1 nCoV-19), encodes the full-length wild-type SARS-CoV-2 spike protein.
While this observation that the majority of cells infected with ChAdOx1 nCoV-19 present native-like spikes on the cell surface (Figure 1B), it is interesting to note that a population may shed the S1 subunit. Whether this is a beneficial or detrimental feature with respect to the elicitation of immune responses during vaccination is unknown. Shedding of S1 subunits from viruses occurs during native infection, and the ChAdOx1 nCoV-19-derived S proteins mimic this native feature of the viral spike.