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User Info Relax Folks: The CDC, VUMC, Johns Hopkins Are All *DONE*; entered at 2021-05-04 12:22:07
Winston2020
Posts: 461
Registered: 2020-03-29
Images of Cells Exposed to COVID-19 Vaccine Reveal Native-Like Coronavirus Spikes
April 7, 2021

https://globalbiodefense.com/2021/04/07/....

The study:

Native-like SARS-CoV‑2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine

https://pubs.acs.org/action/cookieAbsent

Key excerpts:

ChAdOx1 nCoV-19/AZD1222 [vaccine] (hereafter referred to as ChAdOx1 nCoV-19), encodes the full-length wild-type SARS-CoV-2 spike protein.

While this observation that the majority of cells infected with ChAdOx1 nCoV-19 present native-like spikes on the cell surface (Figure 1B), it is interesting to note that a population may shed the S1 subunit. Whether this is a beneficial or detrimental feature with respect to the elicitation of immune responses during vaccination is unknown. Shedding of S1 subunits from viruses occurs during native infection, and the ChAdOx1 nCoV-19-derived S proteins mimic this native feature of the viral spike.
2021-05-04 12:22:07