Additional lab and animal research presented in both papers revealed erythritol and xylitol may cause blood platelets to clot more readily. Clots can break off and travel to the heart, triggering a heart attack, or to the brain, triggering a stroke.
This is much like seed oils: You can't consume any material amount of them eating the plant, simply because there's almost none there.
But then comes along our alleged "Food Safety" organization the FDA and labels unlimited use of these substances "generally recognized as safe."
Without any long-term evidence because, well, it takes a long time to find long-term evidence, does it not?
Oh, if you buy stevia "blends" they typically have erythritol in them which is another close analog to xylitol!
Where is xylitol, in my opinion, very useful and has no appreciable risk? In toothpaste. Why? Because you don't eat toothpaste, but the bad bacteria that cause decay and gum disease (Streptococcus mutans) will eat it thinking its sugar but they can't metabolize it, and thus it is an effective poison to said bacteria, which is good since it selectively kills those bacterial but doesn't tamper with the rest of the mouth's biome. These days I make my own out of coconut oil (for binding), xylitol, baking soda and some cinnamon oil (for taste) as this way I don't have any other crap in it that I don't want. It works perfectly well to clean my teeth and is literally dirt-cheap since, of course, you only use a little bit at a time (a tiny Rubbermaid container about half-full which takes me less than 5 minutes to mix up lasts a month or more.)
Just get the damned carbs and seed oils out of your diet. Do it for a while and you'll find that most things with sugar in them are too sweet and no longer taste good. Its an addiction and trying to play chemical substitute is asking for trouble.
If there's one that I'm willing to risk its stevia in pure form and only in tiny amounts. Its not suitable for cooking or baking (at all; all the concoctions that claim they are blend in sugar alcohols which are manifestly unsafe) but if you want something in your coffee it's arguably the best of the alternatives to actual carbohydrate. There is some evidence it is not entirely benign but then again this is true for most plant extracts in sufficient volume (witness plant-based oils) as since a plant cannot evade or fight off a predator being poisonous in some degree is one of the few defensive mechanisms available.