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2024-05-14 07:00 by Karl Denninger
in Personal Health , 634 references
[Comments enabled]  

Ten years from now there are going to be an utterly-huge number of people who are permanently screwed or dead:

The latest KFF Health Tracking Poll finds that about one in eight adults (12%) say they have ever taken a GLP-1 agonist – an increasingly popular class of prescription drugs used for weight loss and to treat diabetes or prevent heart attacks or strokes for adults with heart disease – including 6% who say they are currently taking such a drug.

Six percent of the adult population is currently using this crap?

Oh fuck.

Yes, I know, they've existed since 2005.  But widespread use only came after a 2017 trial end for Ozempic so we really have about five years of clinical, widespread use and of course originally few people did use it simply because it takes time, so let's call it five years.

Reality is that there is a zero-side-effect risk way to get the same result: Stop eating fast carbohydrates and seed oils.

We do not understand the endocrine system sufficiently to safely tamper with it in this way on a widescale basis.

It is true that GLP-1 is naturally produced in the body.  However, the naturally-produced hormone breaks down very rapidly and this is the natural cycle in your digestive and endocrine system from that substance.  The entire point of these artificially-produced GLP-1s is to not break down rapidly, and these are not actually GLP-1 because that won't work (for this reason); instead they are drugs that bind to the receptor that GLP-1 normally attaches to but unlike GLP-1 they are designed not to break down rapidly.

Now there is a second set of these drugs that binds to both GLP-1 and GIP receptors.  Again, they're designed not to break down as the naturally-produced substances do.

Where have we seen problems with this approach in other things?

Oh, like in everything that has ever been used in the human body and designed to not degrade!  Like, for instance, hydrogenated oils and the covid shots which used pseudo-uridine to prevent the immune system from targeting it because unlike uridine the immune system didn't tag it as "not self" -- in other words, designed to not degrade.

I'll make the prediction now: This is going to utterly horsefuck a huge percentage of people who take this crap, we won't know how badly for another five to ten years -- and more for the continuing evolution of new ones that are in the pipeline -- and most of those bad effects, if they get you, will be PERMANENT (or worse -- fatal.)

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2024-05-02 07:00 by Karl Denninger
in Personal Health , 13841 references
[Comments enabled]  

Remember asbestos?

It was thought to be miraculous stuff.  It is nearly 100% chemically inert.  It does not burn, evaporate, dissolve in nearly all liquids or undergo material chemical reactions with nearly everything.  The exception is strong acids.

As a result it was believed to be extremely safe around humans and animals, in that it didn't chemically react and thus would not biochemically react.  Of course you could choke on finely-divided powder and similar which would be extremely serious because being that it didn't dissolve in anything your body couldn't eliminate it either, but other than that nobody expected trouble with it.  It was used all over the place for insulation, fireproofing and similar for this reason.

Everyone who believed that was wrong.

The astounding thing is that nobody, after we discovered this, went back and revised their view of cancer in light of that which was then proved.

That is, there are two "cancer" related things: Those that cause cancer and those that promote cancer.  They're not the same.  To cause cancer a thing must be active either at a serious biochemical or nuclear level.  That is, ionizing radiation causes cancer because the radiation literally damages the DNA and, if that occurs during mitosis you can wind up with a cell that has no (or wildly dysfunctional) regulatory growth factors. Likewise a biochemically-active substance can damage the cellular machinery while division is taking place, resulting in a similar outcome.  That makes sense.

But we live in a universe where these causes are always present all around us.  Specifically, our planet is chock full of natural ionizing radiation sources.  The most-damaging of these are alpha emitters; an alpha particle is a helium nucleus and as radiation sources go it is very large (as compared with beta, which is an electron, or gamma, which is more-akin to energy such as light or radio frequencies, but at much higher levels of energy and fundamental frequency.)  Because alpha is so large on a comparative basis it is much more likely to hit and disrupt part of a DNA strand -- and thus cause cancer.  While intact skin is enough to block alpha particles there is no intact layer of dead skin in the lungs as that would prevent gas exchange, nor is such present in the intestines or there would be no nutrient absorption and both of which must happen for life to continue so any alpha-emitter you inhale or ingest can trivially cause cancer.

So why doesn't everything die of cancer shortly after coming into existence?

Because you, and everything living animal around you, have an immune system.  The fundamental job of the immune system is to find anything that is "not self" and destroy it.  This is the miracle of organized multicellular life and without it nothing with a life cycle of significant length would exist.  Yet we do exist, as do birds, mice, cats, dogs, ferrets, cows, elephants and so on.  We exist because the immune system finds these dysregulated cells, realizes they are "not self" and destroys them -- and so long as it successfully does so you do not have "cancer" in a clinical sense -- although in point of fact every one of you do, indeed, have cancer in you.

Oh by the way we have an extraordinarily incomplete view of precisely how the immune system works -- how it determines, for example, what is "self" and what is not and how all the components work together and under what circumstances they do, and don't lead to a correct -- that is healthy -- outcome.

Given this, however, how is it that a chemically inert thing can promote cancer?  That is, by what mechanism can asbestos do that -- because we know it does.

There's only one logical explanation: It causes inflammation in the body, that is, the immune system knows it is "not self" and tries to eliminate it but cannot because the substance is chemically inert.  The attack on it is thus unsuccessful but the immune system does not give up since the "not self" is still there and that eventually leads it to fail to detect other cancerous cells in the vicinity and be unable to destroy them.

That is, asbestos doesn't cause cancer (because an inert thing can't cause something) but it does promote cancer.

The distinction is important.

It has also been ignored.

Well, that was ridiculously and I'd argue criminally stupid.

Additionally, it has been discovered that the mRNA vaccines inhibit essential immunological pathways, thus impairing early interferon signaling. Within the framework of COVID-19 vaccination, this inhibition ensures an appropriate spike protein synthesis and a reduced immune activation. Evidence is provided that adding 100 % of N1-methyl-pseudouridine (m1Ψ) to the mRNA vaccine in a melanoma model stimulated cancer growth and metastasis, while non-modified mRNA vaccines induced opposite results, thus suggesting that COVID-19 mRNA vaccines could aid cancer development. 

The mRNA covid jabs deliberately substituted out uridine, an amino acid, for a synthetic pseudo-uridine because without doing that the mRNA material was rapidly and efficiently identified as "not self" and destroyed by the immune system, preventing it from working.  In other words the developers deliberately used a substance that "looked like" (to transcription in the cell) uridine but the immune system was incapable of detecting and destroying it.

Now we have hard evidence that doing this causes the promotion of cancer.

Isn't this exactly what happens with asbestos by the same mechanism?

It is.

The immune system cannot destroy asbestos because it is chemically inert.  Pseudo-uridine was chosen specifically because the immune system did not tag and destroy it; without doing that the mRNA material never got delivered into the cells in sufficient quantity to produce enough spike to elicit a response before the immune system tagged and destroyed it.

What led people to believe that doing this was safe when we had a former example where it definitely was not, and yet the body knew it was "not self" because no such thing as pseudo-uridine exists in the body -- any body, of any animal, anywhere -- in the first place!  Well, of course we didn't look -- looking takes a lot of time, in fact many years, because cancer doesn't show up right away most of the time.

But there was every reason to believe you'd get fucked by doing this given our history with asbestos and oh, by the way, the same thing is true for machine-made seed oils, especially hydrogenated ones that are specifically designed not to break down.

The underlying cause is likely sustained and systemic, artificially-induced inflammation that the immune system cannot clear because the substance in question is not able to be destroyed by the immune system -- or in the case of seed oils in addition to them being engineered to not be destroyed (e.g. so they're "shelf stable" in the store without refrigeration) you keep introducing more of it by eating more and more of it.

Proved?  No, but a hypothesis that fits known facts and both explains the increase of cancers that initiated with ever-larger consumption of seed oils in fast food, fast casual and other dining away from home despite large decreases in smoking and thus smoking-related cancers and at the same time explains the FURTHER cancer increases we are seeing post-covid mRNA shots.

Yeah folks, you did a really fucking stupid thing if you took those shots and if you keep eating seed oils you are increasing your risk even further.

You can't un-take the shots but you can stop eating seed oils.

PS: What mitigates, to at least some degree, this risk?  Increasingly the evidence is...... Vitamin D.  In other words, the sun (in moderate amounts) and during months when you can't get enough that way, which for most of the US or darker-skinned people is at least half the year, reasonable levels of supplementation.  No, its not a panacea, but being deficient has no upside and plenty of potential downside both when it comes to infections and cancer -- and its either entirely free or extremely cheap to make sure you're not.  Oh, and what else are we told?  Stay out of the sun.  Yeah.

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2024-04-25 07:00 by Karl Denninger
in Personal Health , 355 references
[Comments enabled]  

Things that make you throw up in the morning.....

More than a third of adults fail to get the recommended seven to eight hours of sleep each night — and the scarcity of shuteye can have a surprising effect.

Lack of sleep can lead to what some experts refer to as a "silent epidemic" — a condition called non-alcoholic fatty liver disease (NAFLD), which affects more than one in four American adults, according to the American Heart Association.


And the worst of it is that Fox states the truth in the next paragraph!

The primary cause is weight gain, along with metabolic risk factors such as type 2 diabetes, high blood pressure, high triglycerides and obstructive sleep apnea, according to Ibrahim Hanouneh, a gastroenterologist with MNGI Digestive Health in Minnesota.

Yes, sleep impairment is likely associated with the problem -- but if you want to know where the poor sleep comes from get yourself an HRV monitor and you can prove it in your own person.

I'll tell you what you're going to find:

  • Consuming food less than four hours before bedtime.  Your body has to divert energy to digestion no matter what you eat.  You greatly increase the disruption if the thing you consume has carbohydrates or seed oils in it.

  • Consuming seed oils at all.  These are all highly inflammatory.  Period.  Inflammation is bad news on a systemic basis and impairs sleep quality.  You think not?  How well do you sleep after you sprain your ankle, which then gets (temporarily) inflamed?

  • Consuming alcohol.  This is entirely ratable with the amount of consumption.  One beer (or drink) will hit your HRV, two hits it worse and three or more leaves you in a situation where you may as well get hammered.  Now perhaps I'm different than some but I wouldn't bet on it given the number of people I've seen the graphs from.

In addition I will point at statins which are known to cause insulin resistance -- that is, Type II diabetes.  This isn't speculation; it's in the prescribing information and again, insulin resistance precedes Type II diabetes and it impacts sleep quality.

The medical system deliberately ignores a very good high-sensitivity marker they could use -- but you can't on your own.  Specifically, hsCRP and fasting insulin will tell you a great deal about  metabolic health.  Fasting insulin will be high long before you actually get Type II diabetes or even an elevated A1c but it is never tested for routinely.  Unfortunately it is very difficult if not impossible for individuals to run simply because there's no finger-stick or non-invasive test you can obtain for either -- both come with a moderate cost and a blood draw.

But realistically you don't need either.  You can "notch test" any specific food or behavior easily using an HRV monitor as follows:

  • Have a baseline (your current behavior) that is reasonably-stable over a period of a week or so.

  • Change one thing consciously and see what change occurs.

  • Reverse the change back to original behavior and see what change occurs.

If the results are inconclusive or there might be something else going on you didn't account for (some ingredient in a food that you didn't think was involved but it is) then repeat the test with a way to exclude that potential confounder.

This costs nothing once you have the hardware and it is conclusive for you and your individual metabolism.

You can also test if you are insulin resistant by simply removing your clothes, standing with your feet, back and shoulders flat against the wall and looking down bending only your neck.  If you cannot see your junk you are insulin resistant.

Oh, and you're also at risk of NAFLD but poor sleep quality isn't the cause, it is one of the effects of the underlying problem.  Solve the problem and your sleep quality will improve at the same time the risk of NAFLD decreases.

Note that the liver it the only organ in the body that can regenerate, so up to a certain point this problem is in fact reversible and thus no, you don't have to live with it and it is not a continually-degenerating condition either -- at least not until the damage gets to be too severe.

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2024-02-11 08:10 by Karl Denninger
in Personal Health , 744 references
[Comments enabled]  

Note: I am not a physician.  I cannot back any of this up against a random controlled trial or even lab testing since I am unwilling to provide "formal" test results into a system that can and will be used to fuck me down the road.  Thus, absent emergent need, I permit no such thing to occur, and there have been no emergent needs in my adult life.

As a result I do not know my serum Vitamin D level, for example.  I do know, however, a number of metabolic things about my person that I can test on my own with available and inexpensive items I can purchase over the counter or online, such as blood glucose, A1c, blood pressure and several elements of kidney function (urine test strips are available OTC and provide quite a bit of information.)

Until and unless I can have actual hard, enforceable privacy, with felony criminal and heavy punitive financial damages for any breach, no matter why or how, along with iron-clad and lifetime statutory guarantees that such cannot be abused now or at any time during my remaining life, my position on this will not change.  I am especially concerned, incidentally, with genetic-related information as that is a literal minefield for all of humanity; the potential on a forward basis to use that data in a discriminatory manner is unbounded and that we cannot typically do it today in most circumstances matters not because you can't change your genetic make up no matter what you do and thus once that data is in someone's hands it can be used to fuck you up the ass for the rest of your life.  If you are one of the fools who used something like "23 and me" and you, or your offspring, get boned 20 years from now you deserve it -- I've repeatedly warned against this.  By the way that company is in financial trouble if their stock price of roughly 70 cents means anything which in turn means all their data is going to end up in someone else's hands and you have no control over any of it if you previously let them have it.  I warned people of this, and now it is going to happen so bend over and grab your ankles; someone, in the future, is almost-certain to screw you with that data if you gave them a sample.

YOU, AND ONLY YOU, are responsible for your own health.  I sell nothing.  I stand to gain nothing by sharing this information.  It is by definition an N = 1 test on one person (me) with one observer of the results (me) and said observations are limited in time to no further along than the present.  I could easily be wrong, but it is my ass, my choice and this is the set of choices I've made.  If you do any or all of this and get fucked its on you; this is fair warning that it is not a recommendation or a "prescription."  I've read a lot of medical papers and taken the time to understand them and interpret them, then test against instrumentation I bought with my own money and against my uniquely-DNA-encoded body, which is different than every other human body, to some degree, on the planet.

Faux Snooz is of course at it again with "surprisingly simple ways to keep yourself healthy" which omit the most important -- what you put in the pie hole and your immune system's status.  I do agree that activity is a very good thing and being sedentary is bad.  And yes, digestion is important.  But note that of course they talk about "recommended vaccinations" which of course means flu and covid and if anything those are the opposite when it comes to immunity because they are a crutch.  If you get measles there won't be any question as to whether you have a serious problem or not -- right?

And of course the "crank up the stupid" has to come in through "organic this and that."  These cocksuckers never passed organic chem, I see -- so what are they -- diversity doctors?  Probably.  Why?  Some of the nastiest chemicals on the planet are organic which makes sense if you think about it for five seconds; being organic they can interfere with you as an organism quite easily.  And of course they entirely omit the Granddaddy of immunity that in fact is likely the most-important of all, Vitamin D, which is impossible to get from the sun if you're indoors, it is impossible to get enough of it in winter for most people in the US and if you're black the problem is worse because you absorb less of it through your skin due to your pigmentation.

So pardon me if I have a jaundiced eye toward you when you ignore the biggest issue entirely and then play the "organic food" game.  This is nothing more than a cheap shot at those without a huge amount of money (that "organic" steak is twice as expensive as the not, and if you eschew it for the breaded chicken tenders or the pot pie in the freezer because of cost, well.... yeah.  Eat the damned steak before any of that other garbage.)


With that as a preamble here it is.

Due to the fact that roughly north of Atlanta, more or less, it is not possible to obtain adequate Vitamin D from exposure to the sun for about six months out of the year for a person of generally-white skin (the more melanin you have the further south that line goes!), Vitamin D is fat-soluble and thus in the winter all you have is that stored in the body, specifically the liver, and that during Covid we discovered that even in Central and South America most people are deficient (which was a surprise to me but it does make sense given how often people simply don't go outside these days) along with the extraordinary correlation between Vitamin D levels and fatal coronavirus infections (essentially zero persons who were not deficient died of it before any shots were available) I have taken the following daily since August of 2021:

  • 5,000 IU of Vitamin D
  • 100mcg of Vitamin K2

It is now nearly 2-1/2 years later and I have suffered exactly zero symptomatic respiratory infections.

The goal is to make sure that I am not severely deficient.  This should do so.  I am 60 and while I spend a lot of time outdoors in summer as we get older it is well-documented that your skin's capacity to make Vitamin D goes down, never mind that nobody likes getting fried and thus we tend to cover up, use sunblock or both.  Statistically-speaking this level is extremely unlikely to cause problems with having too much -- and the K2 is a buffer against that, although the base risk is very small.  Excessive Vitamin D levels are dangerous, including the possibility of precipitating calcium drop-out in the arteries which might be permanent, but there is quite a wide band before that area is reached.  I will note for reference that at one point during the pandemic Fauci stated that he took twice this amount daily.  I am uncomfortable with a higher amount and again, there is risk of possible permanent and serious damage if you go too far -- then again nearly anything is poisonous in sufficient quantity.  Were I younger and active outdoors on a regular basis I would use this only from roughly October to April -- but the key here is both age and regular outdoor exposure, as that study work during Covid in Central and South America showed.

There is, by the way, an argument for adding magnesium.  If you eat seafood, dairy and green vegetables you probably won't have a seriously-low level and too much is not good -- but if not you might want to add it. Just be aware that as with Vitamin D it is possible to overdose.


  • Vitamin C, liposomal

I keep a stash of Vitamin C around and at the first hint of any sort of respiratory trouble I gobble it in moderate size.  That is, if I feel a bit "off" at night before going to bed (e.g. a bit of a tickle in the throat, etc.) I will gobble up 3-4 grams of the liposomal form of it in capsules.  I am not concerned about overdosing since it is basically impossible to do in a way that will harm you, although getting the squirts, which will happen if you take too much of it, isn't very pleasant.  When I had covid I used a huge amount of it and never found that alleged "bowel tolerance", so the claims of your tolerance going way up when you're sick are, at least for me, very true.  I also will take 2-3 grams of it at once one time a week simply because I do not eat much citrus and while I do routinely eat green vegetables (and they are an excellent source) they're intermittent enough that I want to make sure I have enough of it.  Humans cannot synthesize ascorbate (Vitamin C) due to an error in our DNA that arose a very, very long time ago similarly to the error in feline DNA that prohibits them from synthesizing Taurine (thus they are obligate carnivores.)  You have to be pretty deficient to get scurvy but there is no downside to having more than you need short of bowel tolerance, so this is a vitamin that I gobble with abandon at any, no matter how small, sign of trouble.

I do not like the "powder" form although I have a big jug of it.  For routine use I am very much not a fan because Vitamin C is ascorbic acid and acid exposure is rough on the enamel of the teeth.  I have crappy genetics in this regard and don't need any trouble there but if I needed extremely large doses in order to fight something off I'd deal with it for a few days.  So far that jug has remained unopened (and I'm not concerned about it "expiring" either.)  For the same reason I would not use chewable tablets; there's no concern about tablets or capsules you swallow as your stomach acid will trivially etch paint so once down the pipe its not a concern.


  • Quercetin and Zinc

Quercetin is a flavonoid found in, among other things, grapes.  It has very decent anti-inflammatory properties alone and for a lot of people (myself included) it works as well as OTC allergy meds such as Claritin.  When combined with Zinc it has antiviral properties.  Being a flavonoid in any reasonable amount it has a statistically tiny risk profile and thus I use it without concern, although again -- not without reason.  I used to have severe seasonal allergies before I went low-carb in eating; they are now minor annoyances, but Quercetin is equally if not more effective than Claritin and unlike every OTC antihistamine I've ever tried I do not build a tolerance to it so I choose it instead in the spring, summer and fall months if I'm having allergy issues.  If I have reason to believe I've been exposed to a viral thing or feel any sort of incipient trouble I hit both it and the zinc for a couple of days.  Note that there is some evidence of potential drug interference with this (not significant risk, but non-zero) so if you're on prescriptions check that first.


  • Claritin

rarely use this today but do keep some around.  There was a small retrospective study during covid out of Spain in severely compromised people (nursing home residents) that showed that immediate use of it had a very statistically significant (100%!) positive impact on preventing the infection from progressing -- with no adverse effects from the treatment.  They bundled the antihistamine with Z-pak but of course that is a prescription drug.  This is logical as it is an antihistamine and has a drying effect on the upper respiratory and sinus area, that is, it changes the environment in the nose, sinuses and upper throat.  That appears to be enough to give the body a better shot at attacking the invading virus before it can break through and cause more-serious trouble.  Prior to discovering quercetin I used to use it on a very regular basis during allergy season as part of a rotation (to evade tolerance build) so I have many years of experience taking it and know it doesn't do anything bad to me.  As such it is now part of my protocol for any incipient upper respiratory infection that I feel coming on, although in the last 2-1/2 years I've only used it once for that purpose -- and didn't get actually sick.  Was it a nothing or did it help?  I don't know but the generic at WalMart or elsewhere is extremely cheap and very safe so having a bottle of it around is an easy thing to have on-hand.  Today I would hit any incipient upper respiratory infection with it immediately given the Spanish data and its known safety profile, never mind that its trivially cheap to keep a bottle in your drawer.


  • NAC

Were I to get a serious respiratory infection anyway I would hit it with NAC and I keep some on hand.  I do not use it all the time because there is some question as to its safety in long term continual use.  However, it is known as an anti-inflammatory, immune modulator and helps with respiratory symptoms.  Therefore were I to get something nasty I'd use it and have it on-hand for that reason, but would stop when the reason to use it is alleviated.  Be aware that if you are using prescriptions you need to check for interactions -- some drugs have known interactions where there is reason to be concerned.  I have not had reason to use this since got covid -- but I do keep it in the cabinet.


That's it.  None of these are expensive, none of them pose material risk (other than possibly NAC if you are using certain prescription drugs), the Vitamin D and K2 are likely to promote a better immune profile across-the board which may extend materially beyond respiratory viruses.

In addition it is now nearly 2-1/2 years beyond when I got Covid and in the time since I have not had any respiratory virus of any symptomatic note at all.  I have hit a few things that felt "off" or where my Garmin has pegged a low overnight HRV without any obvious provocation (e.g. a few beers at the bar) with the above protocol and none turned into actual illness.  Statistically, for me, this is quite significant as my "usual" in my years on this rock have seen me get some sort of minor respiratory infection once or twice and more years than not a mild to moderate flu (and once in a while, a real ass-kicker such as the first week of 2020) on top of it.  To go nearly 2-1/2 years with zero such illnesses is quite remarkable in my experience, yet there you have it and, given that experience, I have every intention of continuing to do so.


PS: What difference could we have made with this set of recommendations, ex perhaps the NAC, on Covid in the United States?  The cost of having this on-hand is less than one "quick test" package and the cost of Vit-D and K2 supplementation is literally pennies a day.  Between that and the Spanish nursing home data it is reasonable to expect that an enormous percentage, and perhaps statistically all of the people who got whacked by this virus would not have died, and few would have wound up in the hospital -- perhaps 1 in 100 who actually did.  Of course nobody would have made any money and there would have been no fear of anything if that was recommended and had worked -- would there?  Something to think about.

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2023-10-11 07:00 by Karl Denninger
in Personal Health , 623 references
[Comments enabled]  

Oh, you thought Covid was bad?

How about a decades-long scam which put a huge percentage of American adults on drugs that are dangerous and do nothing in terms of improving your odds of not having the ultimate bad thing happen -- death?  How would you like it if it was proved that your doctor lied, pharmaceutical companies lied, the government lied with their "recommendations", everyone lied -- and many of your friends and family suffered insane deterioration of their condition and ultimately died as a result?

Well, all of that happened.

You were told that cholesterol -- specifically, non-HDL (that is, LDL) cholesterol, was a cause of death via heart attacks and strokes.  You were given medication and told to take it, specifically statins, which do in fact lower cholesterol.  But statins have serious side effects and while they don't screw everyone who takes them (gee, where we have seen that in the last couple of years?) they do, in every case, result in detectable metabolic damage.  That's true for basically all drugs by the way: The question is always whether the damage from the drugs, and by the way those are averse effects, not "side" effects, and are deliberately misnamed in order to mislead you, is greater or lesser than the benefit from taking them.

If the benefit is zero then it is not a drug -- it is a poison.

Well here we are....

Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. 

Wow, that sounds like five things you can change to modify your risk of dying.  That's a great thing, right?

So what were the five things?

BMI, systolic blood pressure (the top number), non-HDL cholesterol, smoking and diabetes.

Two outcomes were assessed: Cardiovascular disease and death from any cause.

I like the latter one far more than the former because dead is dead and why is irrelevant if you're the one who's dead.  We all can wring our hands on the  "why" when it happens, but from the perspective of the "trial of one" it matters not one whit.  In other words I'm not impressed in a "reduction" in cardiovascular disease if the thing that we do to produce it kills you in equal numbers, thus doing nothing has the same ultimate outcome.  Indeed that is a wild-eyed scam as the "something" that a doctor or other medical professional does is never free so unless you can demonstrate all-cause mortality benefit the only person getting actual "benefit" has to be presumed to be the doctor, hospital or pharmaceutical company -- and not you.

Further, this was an extremely large cohort -- roughly 1.5 million people.  Statistical power is greatly enhanced by large numbers, so that they looked at an utterly huge number of people is an excellent factor in favor of the results being valid.

Of the factors, however, only three of the five actually had a statistically significant correlation with being dead: Smoking, diabetes, and blood pressure.

LDL Cholesterol did not; it had a weak association that faded with age with cardiovascular disease but not dying in any of the age groups, which strongly implies that there is no value whatsoever to trying to reduce it in terms of being dead, which is what matters to you In addition, which did surprise me a bit, being fat itself was not dangerous in terms of killing you.

Smoking had the expected negative effect and so did blood pressure elevation.  The latter, of course, is highly-associated with body mass but there are fat people with normal blood pressure.

And finally, diabetes was the Gorilla in the room; at all ages it was a serious risk factor, and not a little either, roughly doubling your risk of being dead all the up until you got to be nearly 80, and even then it was good for a 1.6x elevation in risk.  At younger ages the elevation of risk was as much as four times.

Oh by the way one of the documented side effects of statins is CAUSING Type 2 diabetes.

In addition the global nature of this data and study has shown that no, the region of the world and thus the genetics of the person is not statistically relevant to the outcomes.  That is, there is no "magic genetic" or "magic dirt" factor involved; this applies to humans no matter where they came from or where they live.  While there are small differences from region to region there are none that stand out as statistical outliers, which is extremely important because one of the tropes often run is that "well, I'm from and thus I don't have to worry about it because I have magic genes."  No you don't, by the data, and if you keep believing that bullshit you are likely to be dead as a result of your own stupidity.

So what do we learn from this study?

  • Your doctor is and has been lying, and so have all the medical "authorities" for decades when it comes to cholesterol.  It is a mild risk elevation for cardiovascular disease but not death, and death is what matters.  The "stomp on that now" approach to medicine in this regard is now proved bankrupt and the billions extracted were at best worthless and at worst poisonous, literally, resulting in an increased risk of mortality.

  • Your doctor in fact raised your risk of dying when he prescribed statins.  Statins have a known adverse event risk of causing Type 2 diabetes, which is proved to be a wild (more than double and as much as four times the risk) of being dead across basically all age groups up until you get to be 80, and even then its roughly 1.6x.  Diabetes kills, period, and anything that increases the risk of diabetes is thus poison, period.  Since lowering non-HDL cholesterol has no mortality benefit at all the consumption of statins has no available benefit to your health, but does have a significant risk of causing a mortal disorder.  You have to be out of your damn mind to consume them given this data.

  • Dietary "guidelines" that include carbohydrates, specifically "fast" carbohydrates such as potatoes, rice, wheat in any form (flour, bread, cookies, etc.) potentiate and worsen glycemic control issues and thus cause diabetes.  So do statins.  We know both of these things are facts.  Any "physician" who, given a lack of body mass or glucose control, say much less both, who does not recommend immediately getting all of that crap out of your diet is making recommendations that raise, not lower, your risk of dying.  This study proves that.

  • While being fat alone does not raise your risk of dying we know being fat raises the risk of blood pressure elevation and diabetes.  If you are fat but not either hypertensive or diabetic the fat alone will probably not kill you and other than the other morbidity factors involved in being fat (joint damage, reduced exercise tolerance and mobility, etc.) since it doesn't make your dead the decision (and yes it is a decision) to be overweight or obese is not likely to give you a dirt nap. However, being fat will, over time, greatly increase the risk of one of the other two things happening and both of those do make it more likely that you will be dead.  The bullet point above, or if you prefer this articlewill both control or even possibly reverse Type II diabetes and at the same time make you profoundly less-fat, reducing the risk of both developing or worsening that and high blood pressure and it costs zero dollars and thus makes nobody rich.  In fact it may make you more-rich in that diabetes, in particular, is extraordinarily expensive when it progresses to insulin dependence, amputations, blindness, kidney dialysis and death all of which are really bad for you but make your doctor, the local hospital and others in the medical system extremely wealthy.

Remember the last three years folks.

You were told that "masks prevented Covid-19 transmission."  Did they?  Did you get Covid despite wearing a mask?  Make all the excuses you wish; if a mask prevents you from inhaling a virus how is it that you got a virus if you wore one?  Obviously you were lied to.

You were also told that "taking the shots would prevent getting Covid and also giving it to others."  President Biden said this, the CEO of Pfizer said this, your doctor probably said it, the CDC said it and so did many others.  Deborah Birx admitted that she knew that claim was unfounded when it was made and said nothing, and she's allegedly one of the "experts."  I pointed out that it was unfounded as the original studies never were designed to demonstrate it.  The White House, it is now known, knew within months there were serious safety signals and ignored them on purpose.  Further, as soon as mass "breakthrough" events were reported, which was as early as April and May of 2021, anyone with two nickels worth of IQ points knew damn well that preventing getting it was a lie too, since if there's a 5% failure rate (for example) the odds of all 20 people in a gathering all having said failure occur at once is less than that of being by an asteroid while getting your mail.  Yet exactly that was reported, repeatedly.

Now we know that the claims that cholesterol will kill you, a trope run for decades by damn near every medical provider on the planet and used to promote billions of dollars in sales of drugs, is in fact false.  Its not only false its worse than false in that those drugs do promote a disorder, Type 2 diabetes, that actually does wildly raise your risk of dying.

The only thing worse than that is that we know how to reduce or even eliminate Type 2 diabetes in a particular person at zero cost by doing nothing more than changing what you eat on a permanent, lifestyle basis.

The choice is yours, of course.

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