|
|
 RSS available
Fact: There is no immunity or protection against The Law of Scoreboards. Did you know: What the media does NOT want you to read is at https://market-ticker.org/nad. You are not signed on; if you are a visitor please register for a free account! |
|
| The Market Ticker Single Post Display (Show in context) |
|
| Top | Login | FAQ | Register | Clear Cookie |
| User Info | Well, Duh. This Is Why It Was Stupid; entered at 2021-08-02 10:05:49 | |||
|
Tickerguy Posts: 203857 Registered: 2007-06-26 
|
@Homelessnomad - Quote:So what's the mechanism for the vaccine ruining N protein protection in those who have already had + recovered from the bug? I get it not imparting that protection if you haven't had it already, but how does a vaccination that only elicits S protein response do anything to pre-existing N protein response? It's known as "OAS" or "Original Antigenic Sin." The body, when challenged, mis-identifies the intruder and produces the wrong thing, which fails to stop the infection. It's a well-known phenomena. Coronaviruses have evolved to evade "S" protein recognition by the immune system, which is why they can infect you in the first place. They do this through relatively-rapid mutation and natural selection for protein complexes that the immune system fails to identify as threatening. This means when you get a natural infection most of the antibody titer is skewed toward "N" protein, which is well-conserved because that's the machinery that makes more viruses and, if it gets fucked with, the virus fails in its essential purpose. The problem with inducing a large "S" antibody titer is that if this is what your body responds with after vaccination it's the wrong thing. If, despite that, the virus gets into the cells your "N" recognition has, on-balance, been suppressed. This is backward since an infected cell, if it is not recognized as infected, will produce viral copies and then lyse and release them. This is likely why the shots are non-sterilizing, incidentally -- but it is also why you get no more protection and may lose protection if you were previously infected. Last modified: 2021-08-02 10:08:11 by tickerguy
| |||