That, bluntly, in other than very high risk people its worthless (but of course expensive):

Among the 1288 participants who received at least one dose of nirmatrelvir–ritonavir or placebo and had at least one postbaseline visit, the median time to sustained alleviation of all targeted Covid-19 signs or symptoms through day 28 was 12 days in the nirmatrelvir–ritonavir group and 13 days in the placebo group, a difference that was not significant (P=0.60) (Table 2). Similar results were observed in the high-risk subgroup (i.e., participants who had been vaccinated and had at least one risk factor for severe illness) and in the standard-risk subgroup (i.e., those who had no risk factors for severe illness and had never been vaccinated or had not been vaccinated within the previous 12 months).

It had zero impact statistically on the time to alleviation of symptoms.  The drug was bought and did not work.

However:

In a planned subgroup analysis involving high-risk participants, hospitalization or death occurred in 3 (0.9%) in the nirmaltrelvir–ritonavir group and 7 (2.2%) in the placebo group (difference, −1.3 percentage points; 95% CI, −3.3 to 0.7).

Problem: There was only one death in total so the difference here begs the obvious question on matching of morbidities and such in the trial arms.  How well was that done, given that they did find among the high-risk people a difference in hospitalization and ICU admittance?  It is not logical for these results to occur when the improvement time did not vary between the high risk and not-high-risk groups.

However, it is what it is.

But the real punchline is this:

From August 25, 2021, to July 25, 2022, a total of 1296 participants underwent randomization and were included in the full analysis population (Figure 1), and 1288 received at least one dose of nirmatrelvir–ritonavir (654 participants) or placebo (634 participants) and had at least one postbaseline visit. 

In other words before full approval by roughly a year the study outcome was known but hidden and not published.  As you probably recall you've seen "If Covid, Paxlovid" commercials yet the study says it won't help you get better faster.  Of course the government was paying for it and had been since late 2021 but again, within just a few months it was known that it didn't work and yet this was concealed.

In fact the FDA had no evidence when they made this statement:

“Today’s authorization introduces the first treatment for COVID-19 that is in the form of a pill that is taken orally — a major step forward in the fight against this global pandemic,” said Patrizia Cavazzoni, M.D., director of the FDA’s Center for Drug Evaluation and Research. “This authorization provides a new tool to combat COVID-19 at a crucial time in the pandemic as new variants emerge and promises to make antiviral treatment more accessible to patients who are at high risk for progression to severe COVID-19.” 

And yet just a few months later the company had in its hands evidence that there was no statistical improvement in recovery time between using it and not, yet that study was not published, the FDA was (apparently) not notified and no statement correcting the record was made by anyone.

Now here we are in 2024 and the data comes out -- after being hidden for nearly two years.

This is the world we live in folks -- plenty of money to be made and yet what you're sold doesn't have to work and nobody has a duty to tell anyone as soon as they know, via a formal study, that it doesn't. In fact the FDA went on to give full approval nearly one year after these study results were known.

Should we expect anything different given what we know happened with Remdesivir where the government continued to pay for it and hospitals continued to push it on patients even after a huge multinational study was completed and published showing it was worthless -- and using it came with the significant risk of destroying your kidney function.

I guess not.

Oh by the way, marketing something as effective when you know that it is statistically worthless is fraud.  It is like selling "brake pads" that you know do not stop a car.  If the law meant anything the entirety of the firm's Board of Directors and all their officers would be under indictment since the money stolen from both the government and patients is in the billions.

PS: Have you noticed anything interesting?  When did "new variants" stop showing up and getting all manner of press?

WHEN PEOPLE STOPPED TAKING MORE SHOTS.

Here 'ya go!

You can take all your "grieving" and shove it straight up your own ass.

Why?

Because the people bleating and "grieving" as government officials are all responsible, personally responsible, for felons like this being on the street after being caught committing crimes involving violence and other serious violations of the law and they are then released without bond and without any sort of monitoring.

Further, we keep seeing their "mothers" and others show up whining about "he diddunuttin" when the facts are that in ChiCONGO said person fired 11 rounds at someone without provocation and in MemCONGO the shooter opened fire without provocation as well.  Yes, said targeted person in both cases happened to be a cop but that's irrelevant; if you fire a weapon unprovoked at someone you deserve it if you get turned into a decent rendition of hamburger.  I have zero empathy if that is the result because it should be the result each and every time.

If it was perhaps you'd think about it before you drew that gun, eh?  I mean let's be real -- even an ape can figure that one out and if he can't, well, then his being dead is better than being alive for everyone else.

In the case in Memphis the shooter was recently arrested in a stolen vehicle with a fully-automatic weapon and was charged with possession of said stolen vehicle and said automatic weapon.  So why the hell was he, having been caught red-handed, on the streets?

I remind you that automatic weapons, otherwise known as machine guns, are illegal to possess unless you have a BATFE Form for each of them and in addition using an unregistered device to make a firearm a machine gun can't be registered anyway.  That crime carries a penalty of ten years in the slammer at the federal level all by itself, never mind being a state firearm offense along with the grand theft auto charge -- both STATE felonies.

So this clown was out on the streets (guess his race -- oh you don't have to, just have a look) as he was released without bond and apparently without any actual monitoring either despite being caught in a stolen car and having an extremely-illegal machinegun.  Oh, and it gets better -- the case is reported to have been accepted for federal prosecution (on the machine gun I presume) yet a County Judicial Commissioner (who they conveniently don't name -- gee, I wonder why) let him out on his own recognizance and without any proactive and effective monitoring.

How do we know this?

The vehicle the suspect was in when the shooting took place was also stolen and he also obviously (and very illegally, as he was now charged with a felony) obtained another gun so that Shelby County jackass who issued the ROR release didn't deter anything at all.

In ChiCONGO the person who opened fire was just released on another felony charge as well and thus was a prohibited person as he was under indictment for a felony and therefore could not legally possess a gun.  Once again he was wandering the streets which means he was let out without any enforced conditions on where he went or what he did -- if said "conditions" were allegedly imposed nobody gave a shit when he wasn't adhering to said constraints and they did not immediately throw him in jail for driving around in his vehicle.

We are well beyond the point where either (1) we have to start cheering when public officials (including but not limited to cops) get capped by these thugs who they all let out after being caught violating the law, with no consequence being paid by said thugs for their actions or (2) we have to start taking out the trash ourselves and impose what amounts to a hard separation between the peaceable citizens and the assholes, including in the second group all of the so-called government officials who think that skin color is a reason for you to be able to steal cars, convert firearms to machine guns and not immediately wind up either in jail or with sufficient bond and monitoring pending trial so you can't steal any more cars or shoot at people.

If the Executive branch of the State will not do its job when their inaction is the direct reason a government employee gets shot I am not sorry, I am not mourning, I am not anything of the sort.  I am instead offering a toast of some FINE single-malt Scotch and a loud "hizzah!" because that VERY SAME GOVERNMENT sat on its ass, let a violent asshole out on the streets when they had every ability to keep him in jail or under effective supervision pending trial AND THUS THE DEAD PERSON, WHO IS PART OF THE VERY SAME GOVERNMENT THAT PUT THE PUBLIC AT DEMONSTRATED EXTREME AND REALIZED RISK DESERVED WHAT THEY GOT.

BETTER THAT SAID PERSON BE THE ONE DEAD THAN AN INNOCENT CIVILIAN WHO HAD NO ABILITY TO DO ANYTHING TO PREVENT THIS SINCE CIVILIANS CANNOT CHARGE AND PROSECUTE, AND IN FACT THE PEACEFUL CIVILIANS IN THE AREA RELIED ON ALL THOSE OTHER ASSHOLES IN THE GOVERNMENT TO DO THEIR JOBS WHICH THEY WILLINGLY AND INTENTIONALY REFUSED BECAUSE SAID ACCUSED WAS A "DINDUNUTTIN BOOOOOY."

Don't give me any bullshit, Governor Lee, about how this was a "local" or "isolated" failure.  You're lying, that is a SIN so your professed faith is ALSO false and here's proof from the Tennessee STATE Statute books:

A person commits an offense who intentionally or knowingly possesses, manufactures, transports, repairs or sells:

• An explosive or an explosive weapon;

• A device principally designed, made or adapted for delivering or shooting an explosive weapon;

• A machine gun;

• A short-barrel rifle or shotgun;

• Hoax device;
  
  
• Knuckles; or
  
  
• Any other implement for infliction of serious bodily injury or death that has no common lawful purpose.

Nevermind that the stolen vehicle is a state felony as well.  Assuming the vehicle was worth at least $10,000 (but less than $60,000) it was a Class C felony which carries a sentence of not less than three nor more than fifteen years in the state slammer.

So spare me any whining about Memphis.  The State had every right and in fact duty to bring State felony charges and take said person into custody on same if the City of Memphis refused to do so and if the STATE had done so he would have been in jail and unable to commit this crime.  Memphis has become a shithole as a direct result of this crap and I want to know how many cops will remain on the force and be target practice for assholes if the county and State will not put a stop to this shit right here, right now, period.

I'm done with all the whining, crying and praying by cops and other so-called "do-gooders", especially the black poverty pimps and their enablers, when this sort of crap happens.

I no longer care when cops get whacked by these thugs nor will I care if any member of the State or Local Government, or any of their family members, get whacked in each and every instance where the offender was previously caught doing something carrying felony penalties and was released pending trial with no monitoring or enforcement of same or, even worse, if they were released with no charges and trial at all!

In both these cases -- and many more -- that is exactly what happened and these same thugs attack, steal from, maim and murder innocent citizens who have no actual power to indict, prosecute or imprison.  That is a power our society has delegated to the Executive and if they refuse to perform their duties under said laws then it is time for all citizens to cheer when they are the ones who pay for that refusal personally, up to and including paying with their lives.

In fact I propose that Friday night become toast a dead government official night until and unless all this bullshit DEI/Racebaiting bullshit STOPS with 100% finality, every time, and anyone who gets caught stealing cars or with an illegal machine gun gets to sit in jail or under effective 24x7 electronic supervision with a nice, high bail to be forfeited if they try to cheat until their trial occurs and if found guilty they do hard time in prison every single time as well.

I know that some counties in this state actually force accountability and monitoring with ankle monitors, cash bonds and similar for far lesser offenses than stealing cars and possessing illegal machine guns.  Shelby County has no excuse for their outrageous refusal to either lock this jackass up or maintain effective knowledge and control of what he was doing post his original arrest and neither does TBI, the State Executive generally and the State Attorney General.

Felony laws related to violent criminal acts just like anti-trust laws are not suggestions but it appears that in basically every jurisdiction, including "Red, Conservative" states such as mine, the violent felony criminal code is in fact a set of suggestions if and only if the offender is black, brown, or some form of illegal immigrant.  IF you are in one of those "protected classes" you can, by this example, literally steal cars and convert weapons to machine guns and nobody will lock you up pending trial nor require any cash bond for either even when you are caught red-handed in the act.

It is for that reason and that reason ONLY that these cops got shot.

FUCK YOU Governor Lee, and all of those in the State and Memphis city prosecutorial and judicial apparatus. YOU DID THIS.

And DOUBLE FUCK YOU to our Legislature, including specifically Speaker Sexton who of course was bleating all over Twitter on this event, a legislature that continues to fund and rubber stamp Executive agencies, including the State Police, State AG and the entire State prosecutorial apparatus who refuse to do their goddamn jobs when city and other local officials will not.  The power of the purse rests exclusively in the Legislature and thus continued funding of demonstrably corrupt entities who refuse to discharge their duties makes our Legislators all direct enablers of these felons.

I reminder Speaker Sexton that Tennessee has an "ouster" law that bears on this situation as well -- it permits an action to remove an official who has violated or corrupted their oath of office, including by willingly neglecting to perform the duties of said office.  When are we going to see that be filed and executed demanding the AG act against the STATE officers, Prosecutors and other officials who refused to step in and arrest this asshole when Memphis did not, along with the Memphis officials as well Mr. Speaker?

Those of us who care about the law and a peaceable society are tired of the excuses made for letting violent, known felons walk away from offenses without detention, monitoring or any other sort of enforced bail condition who then go on to commit further offenses of the same seriousness or worse than what prompted the original arrest.  This deliberate malfeasance is directly responsible for serious property and personal crime across this and every other state where it occurs and now it has directly resulted in both maiming and death.

Fix it right now or may you all be damned.

.... isn't that cancer rates are rising in young people.  That's expected given what else we know is going on.

Accelerated aging — when someone’s biological age is greater than their chronological age — could increase the risk of cancer tumors.

That’s according to new research presented this week at the American Association for Cancer Research (AACR) Annual Meeting in San Diego, California.

"Historically, both cancer and aging have been viewed primarily as concerns for older populations," Ruiyi Tian, MPH, a graduate student at Washington University School of Medicine in St. Louis and one of the study researchers, told Fox News Digital.

No, what is infuriating is that nobody has done a damn thing about the obvious correlating factors that have been known for the last two decades and yet both are continually not only dismissed but in many cases "celebrated."

I am speaking particularly of obesity, insulin resistance, diabetes and the combination of seed oils and fast carbohydrates, the latter two of which are known to promote both obesity and systemic inflammation.

The hope is that these findings will lead to interventions to slow biological aging as a "new avenue for cancer prevention," the researchers noted, combined with screening efforts tailored to younger individuals.

Interventions is a fancy word for "more drugs" and "more affirmations" rather than what is actually needed, which is subtraction.

Specifically, subtracting out the bullshit that one is "healthy at any size" (you are not -- you are disgustingly fat and quite likely to become seriously diseased if you keep it up), that fast carbs and seed oils are "ok" to eat in any quantity and in fact can be peddled almost-universally anywhere you eat away from home, that so-called "heart healthy" and other "health" foods can be sold with one or both of these things in them (go pick up a box of granola bars and you will find seed oils in them) and more.

Diabetes Mellitus is otherwise known as the mother of all diseases -- and it is.  Insulin resistance is detectable for a long time before your glucose or A1c goes out of range yet fasting insulin is never tested for on a routine basis.  Cholesterol is a necessary thing and part of the body's repair mechanism -- it is not the cause of disease it is the result of systemic inflammation which frequently traces to insulin resistance and it is made in the liver by the body.  And what's worse is that statins, which are often given to reduce cholesterol levels, has as a documented "side effect" causing Type II diabetes -- that is, extreme insulin resistance that manifests as actual, current and mortally-dangerous disease.

Of course nobody will go to prison for poisoning millions of Americans -- say much less anywhere else in the world -- all because its ten cents cheaper to use a seed oil than something else in your product and it is also ten cents cheaper in the restaurant yet none of those places even disclose said content in their food nor will one single medical group or physician be thrown in prison for causing -- literally -- "the mother of all diseases" in millions of Americans.

Think not?  How about a bagel?  Yeah, I know, it has gluten in it, but many people have no problem with that.  Everyone, however, has a problem with this:

There it is: Soy oil.  Why is it used?  Its a bit cheaper but the safe amount of it to consume is in fact zero.

Ok, so bagels aren't good for you (that's got 45g of carbs in one, by the way, so there's your entire 50g low-carb daily budget blown with one bagel!) so we'll reach for the granola bars instead:

Oh, that's just lovely.  "Just" 30g of carbs and that's better than 45, but note the Canola and Sunflower oil so we're back to that problem.  Oh, and "contains soy" it says, despite not being listed in the ingredients so is the oil declared actually the oil present or did they stick a "surprise" in there for you -- or is it simply the Soy Lecithin?  Finally, note the bottom: Contains Bioengineered food ingredients -- what's that?  Good question but do note that these are claimed to be a "health food" and "good for you" unlike the bagels.

Leave the carb debate out of it: The seed oil garbage and their derivatives are highly inflammatory and IMHO should not be consumed at all, but essentially every package product food maker uses it because the FDA "blessed" it by considering it "generally recognized as safe" (that's a lie), its cheaper and products made with them are shelf-stable -- that is they can be boxed without refrigeration -- and this is far more important than whether it kills you over the course of 30 or so years since nobody is ever held accountable for all the disease, disorder and death that comes from it nor do they have to truthfully label said packages that they are all extremely inflammatory and systemic inflammation is directly harmful to your health.

Another example you're going to run into in virtually any restaurant, with no disclosure?  Right here -- note the claims:

Whirl is 65% lower in saturates than butter. It also contains 5 times more polyunsaturated fat and 2 times the amount of monounsaturated fat than butter which equates to being a lot better for you. Not only is it better for your health, it is also much easier to handle and cook with. It does not spit or scorch and is easily stored, as it doesn’t need to be refrigerated.

Oh really?  What's in it?

Soybean oil, Hydrogenated soybean oil. Contains 2% or less of Salt, Sunflower lecithin, Artificial butter flavor, Beta carotene (color), Yeast extract.

That's a trans-fat and the safe amount of consumption of trans-fats is zero.  Vegetable oils are hydrogenated to prevent them from spoiling -- which also inhibits digestion and causes both inflammation and other maladies.  They're a literal heart attack in a bottle and ought to be banned -- but if you did that half the "foods" in the center aisles of your grocery store would become illegal.  Saturated fat, by the way, is not the cause of heart disease, is not inflammatory and also greatly contributes to satiation -- that is, not being hungry.  We can't have that, can we, or you won't come back for lunch!

Never mind the same sort of burying the evidence in the pharma business, which I've got an article coming out on soon with regard to one specific example which I warned against some two years ago.

And yes, I do believe, based on the data, that the so-called "magic jabs" are responsible for part of this increase as well.  But not all of it for the simple reason that while cancer rates in older people had been declining for a couple of decades but have now reversed and are trending higher, and that inflection occurred starting in 2021 which happens to be exactly when the magic jabs rolled out the rate increase in younger people pre-dates that -- and no matter what sort of magical thinking you may be infested with something can't cause an outcome when the something hasn't happened yet.

Not "might be", ARE PERMANENT.

From the Mayo Clinic:

Remarkably, 100 % of GD patients were under PB treatment including 9 patients (56 %) at the time of FP surgery, highlighting the widespread nature of PB intervention in this demographic (Table 1). Although sperm collection was suggested, all GD patients opted for FP surgery due to reluctance or inability to ejaculate. Two out of 9 PB-treated patients exhibited abnormalities: one had bilateral abnormal testicles with a lack of complete tunica albuginea, while another had a right testis that was not easily palpable. The remaining patients displayed scrotum symmetry with bilaterally palpable testes.

They could not provide a sample the old-fashioned "squirt it" way and two out of the nine had abnormal testicles on simple manual examination, not requiring any sort of investigation.

For the sex gland study, we digitally scanned 400+ Hematoxylin & Eosin-stained donor testicular biopsy sections available in Mayo Clinic tissue registry. We analyzed testicular specimen with and without PB exposure. The histology results showed abnormal testicular development in PB treated compared to non-treated patients (Figure 2A-B).

The evidence is that these puberty blocks result in abnormal testicular development -- in other words they screw you to some degree on a permanent basis in terms of what would otherwise take place.

 For example, sex glands of a 12-year- old patient treated with leuprolide and estradiol (E2) for a period of 14 months had 59 % of sex glands fully atrophied with appearance of microlithiasis (Figure 2C-D).

Fully atrophied: Non-functional, presumably permanently.

Meiotogenesis is generally assumed to be absent in normal pre-pubertal children due to lack of sperm development. Remarkably, we observed spermatid-like cells across all juvenile stages, including newborns. The proportions of pre-meiotic (SPG 1/2/3, L/Z-SPC) versus post-meiotic (P/D/M-SPC, Spermatid 1/2/3) spermatogenic epithelial lineage reached up to 12 % of the total spermatogenic epithelium in prepubertal stages. In fact, PB-treated juvenile patient exhibited 7 % spermatids within spermatogenic epithelial lineage (Figure 3C; Figure 4A and Supplementary Figure S3).

We revealed a striking molecular clustering of pre-pubertal spermatid-like cells, challenging conventional assumptions about their developmental trajectory post-pubertal onset (Figure 3C). Furthermore, our analysis of significantly differentially expressed genes in pre-pubertal spermatid 2 and 3 compared to their adult counterparts suggests a potentially novel induction pathway independent of puberty (Supplementary Table S1 and Supplementary Table S2). This pathway leads to likely incomplete differentiation, resulting in the development of spermatid-like cells without subsequent sperm maturation and warrants investigation.

The presumption has been that prior to puberty there is no development of said sperm-generating cells in the testes.  This apparently has never been actually studied, as these researchers found that in fact these cells are found in normal pre-pubertal boys which of course means that the entire premise -- that you can't damage what isn't there -- is now known false AND WAS ORIGINALLY PUT FORWARD WITHOUT STUDY AND THUS WITHOUT EVIDENCE.

Note that this study has not yet been peer-reviewed but it points out what I have maintained since all this started: We do not understand on any sort of comprehensive basis the natural progression and interplay of all the elements in puberty nor do we have sufficient knowledge to know what happens if you tamper with it, even temporarily.

This study shows that said tampering is very likely to lead to permanent dysfunction if it occurs at the time when normal puberty would otherwise take place.  The promotion of these drugs as "safe" based on their use in precocial puberty was maliciously false in that it was promoted without a single shred of scientific evidence and now, based on actual study, we know it was false and the boys given these drugs were maimed.

I will point out that we know even less about the impact on girls given drugs for similar purpose because obtaining scientific evidence from samples is ridiculously more-complex and dangerous than it is in boys, since to do so requires significant surgery and attendant risks of permanent infertility or worse.  As a result it would be virtually impossible to obtain review clearance for such a study, particularly on the control side, except perhaps from those young girls unfortunate enough to die of non-disease related causes (such as a car accident.)  Again, there is no evidence that giving drugs to a pre-pubescent girl is benign in this regard nor is there any evidence that doing so does not carry a high risk or even certainty of permanent reproductive impairment.

This very closely mirrors my argument and, as time has gone on, facts have proved me right in multiple other areas of alleged "medical science."  But in this case we are talking about children who simply cannot give informed consent and thus a lack of certainty is simply not acceptable when the condition in question has no physiologic basis nor can the alleged "remedy" be successful as it is not possible for a boy to ever be a functional adult female in a sexual (say much less reproductive) context, and vice-versa.

What these kids are seeking, whether they legitimately feel this way on their own or have it stuffed in their head by their caregivers and peer pressure -- to be the other sex, to experience it, to feel it -- is physically impossible.  Telling them that it can be done is a deliberate and malicious maiming of said child's normal sexual life which they would otherwise experience when they reach puberty and adulthood.  This is as clear an example of fraud as one can find as that deception in fact creates a lifetime dependence on and flow of payments into the medical system.

This practice must be immediately halted and everyone involved in or advocating for it must go to prison for said permanent maiming and what is clearly sexual abuse of children for profit as the acts in question are aimed at diddling the genitals with no possible medical outcome that matches what is being either offered to or expected by the recipient.