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User Info 2020-03-25 Models .v. Data (Podcast); entered at 2020-03-25 16:29:48
Naomi_cas
Posts: 977
Registered: 2007-08-17
Personally, I never look at other people's models...it is just not fun for me. I find a lot more effective to just look at the data myself. I do have the ability to not give a f... about what anybody says, whoever they are (that helps I am sure). Yes I have been called an iconoclast. I like to work alone, I would hate to work in government.


Speaking of live vaccines:

"Can a century-old TB vaccine steel the immune system against the new coronavirus?"
https://www.sciencemag.org/news/2020/03/....

"Vaccines generally raise immune responses specific to a targeted pathogen, .... But BCG may also increase the ability of the immune system to fight off pathogens other than the TB bacterium,...work in Guinea-Bissau concluded the vaccine prevents about 30% of infections with any known pathogen, including viruses, in the first year after its given."

About this novel mechanism:
https://science.sciencemag.org/content/3....
"protection from reinfection has been shown to occur independently of T and B lymphocytes. ... This model of innate immunity can display adaptive characteristics after challenge with pathogens or their products. This de facto immunological memory has been termed trained immunity or innate immune memory. "a previously unrecognized property of human immune responses."
Trained immunity would involve epigenetic reprogramming as oppose to genetic (DNA code) changes.

Fascinating.

How long can you derive BCG benefits? ie how stable/persistent are those epigenetic changes? people born in Europe decades ago all got this vaccine, I did. People seem to think it lasts only months, but epigenetic changes can last thru generations, so why does it have to be short lived?

Needless to say all medical personnel would probably opt for this vaccine ASAP if they have not had it yet. I seem to remember there are "attenuated forms" of it for kids with lung issues (chronic bronchitis etc..).

New virus= new findings.


2020-03-25 16:29:48