If You Wonder Why Medical CURES Are So Rare....
The Market Ticker ® - Commentary on The Capital Markets
Posted 2012-08-08 22:10
by Karl Denninger
in Health Reform
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If You Wonder Why Medical CURES Are So Rare....
 

Type 1 Diabetes is a nasty disease in which the islet cells in the pancreas are destroyed by the body.  This renders the sufferer unable to produce insulin, which is necessary to regulate the metabolism of glucose (sugar), the body's main fuel.

Without insulin you will die.  Type 1 diabetics must therefore inject insulin, either through the use of a pump or manually using syringes, literally through the day and manually test and regulate the blood sugar -- a process that healthy people's bodies do automatically.

It has been assumed that this condition, once it developed, was essentially incurable, although there were some people who believed that stem cells might be able to be "turned on" to replace the destroyed islet cells, or that we might some day come up with an artificial pancreas.

What I bet nobody assumed was that a relatively inexpensive, and 90 year old vaccine might actually cause the body to repair itself.

It looks like that may have been discovered.

A tuberculosis vaccine that has been in use for 90 years may help reverse Type 1 diabetes and eliminate the life-long need for insulin injections, results from an early study by Harvard University researchers suggest.

...

“These patients have been told their pancreases were dead,” said Denise Faustman, director of Harvard-affiliated Massachusetts General Hospital’s immunobiology laboratory, who led the study. “We can take those people, give them a very low dose twice and see their pancreases kick in and start to make small amounts of insulin.”

This is the sort of breakthrough -- the possibility of an actual cure for a condition that has always been regarded as utterly incurable -- that you would think everyone would be jumping all over to test and develop, right?

Wrong.

And why not?

Faustman and her colleagues at Massachusetts General inBoston are working to get the vaccine to market. After their early findings in studies with mice, she said they tried to interest every major drugmaker in developing the vaccine as a possible cure for diabetes. All told her there wasn’t enough money to be made in a cure that used an inexpensive, generically available vaccine, Faustman said.

Got it?

It's not about people or health.

It's about money.

The implication, of course, is that if it's more profitable to "control" a disease than cure it, the path that will be pursued is "control", not cure.

Are all these chronic conditions that we suffer from truly incurable? 

Or is it simply that nobody looks for actual cures, because it doesn't make as much money as "therapies" do?

It was a bit different when charities were providing a good part of the care.  Then you had people actually interested in cures, because the funds were privately provided and the more people you could cure the more people you could help.

EMTALA and the rest of the mess our government put in place in the health system broke the incentives that would normally be associated with medicine, and we all get screwed as a consequence.

Discussion below (registration required to post)
 

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User Info If You Wonder Why Medical CURES Are So Rare.... in forum [Market-Ticker]
Swampwoman
Posts: 366
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NE Florida
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Hunh. And I read it as no drug company is willing to take on the millions of dollars' worth of testing for something that would not bring a financial return to their company.

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Mrbill
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Of course not. The *incentive* is with everyday folks, people with the disease or who want to see it cured.

Those are the people that need to pay the researchers and pay for the testing.

That includes me. How do I give to this?
Campbeln
Posts: 31
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Canberra, AUSTRALIA
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Hate to say it Gen, but this is one advantage of single-payer healthcare systems; they are about cost minimization and have the money behind them to exert gravity in this sort of case (one would hope that some of the world's health systems are doing so now with this discovery).

Of course, just because you have a single-payer doesn't mean private doesn't exist. Australia has both public and private. And while not perfect, it works quite well (so long as you're within population densities that make sense for a cardiologist, etc.).

Also, with the obvious regulatory capture in the US in other areas, who's to say how much of the FDA trials are more about barriers to entry then public safety (and with Vioxx, FenFen, how well do they work anyway)? Of course, much of the rest of the world relies on FDA approval rather than employing their own testing...

Maybe an IMF-like international health care establishment would be a good idea? Countries pay a percentage into a central fund that manages testing such as this "for the good of humankind". Of course, basing anything off the IMF makes me feel dirty, but there is some logic there non-the-less...

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My friends call me "**** yourself, liberal trash" http://market-ticker.org/akcs-www?single....

Reason: added IMF-ish suggestion
Stonecold
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Drugs can be given for off label use.
Genesis
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Actually Campbeln, it doesn't. How well would it work if Australia had to pay the pro-rata development cost of all the drugs you use that we pay for the testing on?

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Lowbeyond
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Maybe it was a birdy bread-bomber from the future?!
Eli
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Every drug maker has a **** ton of drugs they sell to treat diabetes a cure would end all that especially a cheap cure.

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Campbeln
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Heh, hey Gen,

Just added that thought to my original post. You are correct, the FDA is "outsourced to" by much of the rest of the world, and that SHOULD stop. Australia SHOULD be paying pro-rata, as SHOULD everyone else (hence my IMF-ish idea above).

EDIT: I DO pay for my families share of FDA research, due tot he fact that the US is the only country in the world who levies taxes earned outside of their jurisdiction. So I'm still paying into the federal budget...

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Ben
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Chris Rock:
Doctors don't cure ****! They don't cure ****! The last disease doctors cured was polio, when's the last time you met someone with polio?

There's no money in a cure. Every dealer knows you make money on the comeback.

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Frat
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Sigh.

It's way past time in SO many ways, it's not funny. This kind of story no longer enrages me, it just makes me SIGH. I'd like to believe there's hope, a possible way for us to fight the machine, but I don't see it. Looking over my shoulder, down on the floor playing with his Legos is the only thing I have to WANT to better this ****hole we live in (and his little sis, of course).

I think I need more range time.

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Bsfootprint
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Disband the FDA. Now.

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Franjime
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The incentive is that if someone finds a cure for diabetes, they will have their names added to a very short list of medical doctors. Jonas Salk? Watson & Crick? Add your name here....

That pharma doesn't want to invest in something that won't make them money shouldn't really surprise anyone, especially the readers of this forum.

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Debtpie
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Martha Flockner...whada ya know...another nail in the "free market" medical care/insurance coffin.

A. The "free market" has failed horribly to (affordably) insure anyone that isn't either wealthy or healthy.

B. The "free market" isn't interested in cures as they're not as profitable as drugs that mask the illness...and in many cases cause other illnesses for which there is another pill...

Way past time to shift the focus from (extreme) profits firsts, to results that benefit the patients first.


Single payer system folks; lets look at Taiwan and improve upon it.

Quote:
TAIPEI, Taiwan — Liu Hsiao-ling, a 58-year-old Taipei retiree, has Taiwanese friends who live in Chicago.

When they get so sick they need to see a doctor, they head for O'Hare and hop a plane for a 20-hour, cross-Pacific trip to Taiwan.

"The airline tickets are less expensive than getting treated in the U.S.," said Liu, as she sat in a hospital lounge in Taipei waiting to pick up her prescription. "And they say going to the doctor in Taiwan is much better than in America."


http://www.globalpost.com/dispatch/china....

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Capeman
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You're asking the question of why pharma companies don't want to shoot themselves in the head by killing their own business with a cure. It's obvious. Nobody is going to make the decision to kill business.

This seems pretty cool and I am all for it even though I work on diabetes treatments for type 1. I've always dared people to put me out of work and I will go find something else to do.

The truth is that you may cure Type I and that would be great but that population is less than 5% of the diabetics in the world. Most all of the other 95% could cure themselves if they wanted to.

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Stonecold
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If they can convince a doctor that it works that is all it would take. Doctors can give drugs for off label uses. we use Avonox all the time for eye cancer. It is not aproved for eye cancer. So it could be used as is, No problem. I doubt it works. There is not reason for it to work. Many people make claims that are false. Look at cold fusion. Or those belly blasting machines
Sean
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I wanted to cure why I was feeling the way I was feeling. So about 3ish years ago I found a great natural doc and she has cured me! Not given me some ****ing pills to be on for the rest of my life!


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Mortgageguymn
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Why wouldn't health insurance companies run their own tests on this treatment and if it's effective, mandate its use, pay for it 100% without a deductible and decline to cover other diabetes treatments without giving this one a crack, too? (That last comment may be a little heavy-handed about declining to cover...).

The point is that while an effective cure for diabetes could cost insulin makers money, it could save private insurers money - just as it could save a Single Payer money. If savings are to be had, I would think insurers would get involved in promoting this treatment.
Mortgageguymn
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Sean, Just hope your "natural doc" isn't a homeopath or you're throwing your money away and possibly foregoing interaction with the reality-based medical community. I'm not against "natural" per se, and I think too many docs are pill-pushers, but if you're seeing a homeopath, you might as well save the money and throw some salt over your left shoulder. All homeopathy is 110% bull****.
Sean
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NMD Mortgageguymn - no worries there.

BTW, I disagree with your All homeopathy - maybe 75%+.

----------
* I think Ann Barnhardt is more and more right. God help us!
* Progressives / Marxists / Communists are many things, STUPID and IMPATIENT are not two of them.
* A hot civil war is coming.
* And people wonder why I prep!
Mortgageguymn
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All.
Hierophant
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Quote:
whada ya know...another nail in the "free market" medical care/insurance coffin.

What free market?
Azusgm
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East Texas
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There are several strains of BCG used for vaccines.

http://www.who.int/vaccine_research/dise....

TheraCys by Sanofi-Pasteur was the brand used here.

This trial was a proof of principle trial (proof of concept). The investigators administered two tiny doses given four weeks apart to three subjects in the treatment group and saw a transient effect in a marker for islet cell activity. This needs more work. The paper is freely available from the Faustman lab website. Here is the link provided from faustmanlab.org:

Faustman DL, Wang L, Okubo Y, Burger D, Ban L, et al. Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes. PLoS ONE 2012;7(8): e41756. Full Paper

At this point, the issue is raising money to continue the research. This interview contains a bit about the editing to which one of Dr. Faustman's journal articles was subjected along with her comments about funding issues. Part I of the interview was pretty readable too.

http://www.diabetesselfmanagement.com/bl....

Bertdilbert
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Why should a drug company go to the FDA to get a use approval for an old drug that provides them no profit protection once they spend the money? In such a case, if it were to be in the public interest, then the public would have to fund the approval or create a system that provides protection for new use of an old drug.

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Vitchilo
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The FDA is corrupted to the bone.

Anyway, since using a tuberculosis vaccine could cure diabete type 1... why does it need research??

Just take a few willing diabete type 1 participants, make them sign a no responsability contract... and do it... Screw waiting for the corrupt FDA to approve anything.... it takes usually 7+ years for anything to be approved even when it's proven to be working.

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